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Toxicity of quetiapine may rise if it s co-administered with the drugs able to affect work of cytochrome p450 which accounts for metabolism of seroquel, these drugs are ketoconazole nizoral , itraconazole sporanox , fluconazole diflucan , erythromycin, clarithromycin biaxin , nefazodone serzone , verapamil calan, isoptin, verelan , diltiazem cardizem, tiazac, dilacor .

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